I agree with Laura, break them in slowly mileage wise. Esp. if you are not a purely nuetral runner. - But heck, maybe you are?? what do I know??
The reason why I say this is, I happened to be talking shoes with an industry rep recently.He mentioned that there were a lot of blister problems at kona this year from a certain "new high dollar shoe". So I took that to mean newtons. Tho I do know there is one other high $$ brand that's come on the scene recently.
I like the technical aspects of newtons (forcing you up on your forefoot), but as I said to the rep "I'm not worthy of a 150.00 shoe. That would be like wearing a TT aero helmet and averaging 16-17 mph on the bike."

Tho it would be nice not to have to strap on the bricks I wear now after being out there all day!