Happy to report that I am one of those doing very well with treatment. The fatigue is real. When my meds are off I end up on my office floor sleeping in the afternoons. Finding optimal treatment isn't always easy. They will probably start you on synthroid (T4), and slowly titrate up your dosage. It takes *time* to see results too. Even though T4 normalized my blood work, I needed a T4/T3 combo therapy to have my symptoms controlled. I think my mistake was letting my internist treat me, rather than going to an endocrinologist sooner. FYI, I do best with 150 ug of synthroid (T4) plus 5 ug of cytomel (T3). T3 is the active form of thryoid hormone that is made from T4. For some reason, that small amount of T3 that was added to my dosing makes a big diff (it was actually not really added but replaced 25 ug of T4 since it is 4X more active).