I am sure that a good LBS can tell shadon if 650c wheels will work on her bike. I sort of doubt it, though. As far as I know, all bike frames are built for one size of wheel, period. Spending bucks for a set in a different size without checking that they will actually work is a waste of time, if not money (I am assuming they could be returned).
I ride 650c wheels on my 46cm Aegis Swift, but that is what it is built for. I carry an extra tube, a patch kit, and two CO2 cartridges, but have never had to use any of it. No, I have not had a single flat since I had this bike built in early 2004 (shhhh.....don't tell the flat gods or I am sure to flat immediately!
) So, I don't worry too much about having an odd-sized wheel since I am a small person riding a small frame, and 700c wheels just wouldn't work for me. As long as I am prepared for a flat, I'm good. And even better if I never get one!
Also, re. the Arkel bags (of any sort), I second the recommendation. I bought a full set of Arkel panniers for my Bike Friday last year for a self-supported tour, and they are simply awesome - amazing quality and very nice looking as well. I reviewed the Tailrider, which is a great little rack pack, on girlbike.com last year and am still loving it. It expands to hold a lot more than it would appear at first glance. Arkel products are not cheap, but they should last many, many years since the quality is definitely there. And the company stands behind the product 100%. Thumbs up!
Emily
P.S. You can see my full Arkel set in my avatar....
Emily
2011 Jamis Dakar XC "Toto" - Selle Italia Ldy Gel Flow
2007 Trek Pilot 5.0 WSD "Gloria" - Selle Italia Diva Gel Flow
2004 Bike Friday Petite Pocket Crusoe - Selle Italia Diva Gel Flow