What is your center-to-center and outside-to-outside sit bone span?
You want the overall width of the sit of the saddle to be a cm or two wider than your outside measurement (so you have wiggle room on the saddle for shifting your weight as you turn, etc.)
You want the centers of each "cheek" of the saddle to be the same as your center-to-center span. The center of the cheek is the part designed to support your sit bone. (find the cheek center by finding the widest part of the saddle. Draw an imaginary line down the very middle of the saddle. Measure from outer edge to middle line, and the center of that is the middle of the "cheek") You can get away with being off the center of the cheek if the saddle has a very flat contour.
If all those measurements match up, then I would suspect you have a saddle that is too pear shaped for your hip angle and you are bruising the tissue at the fold (which is quite near the ischial tuberosity) of the buttock by slamming it into the transition of the saddle as your hip moves through the pedal stroke.
If you can sit on a wooden church pew or a wooden kitchen chair without the same kind of pain, then your sits should be plenty tough enough already. If sitting on such a chair does cause you a lot of pain and leaves you just as sore, then your sits probably do just need to toughen up.
"If Americans want to live the American Dream, they should go to Denmark." - Richard Wilkinson