Not necessarily. Some of my knee pain problems are a result of overdeveloped quads, relative to my other leg muscles. I find that I have a habit of leaning too far forward, rounding my back, and tucking my tailbone under which makes me rely too much on my quads. This posture gets me in trouble in almost all situations: riding seated in the saddle, standing up out of the saddle going up a hill, walking up stairs, walking up a hill, backpacking, etc.
I have to consciously stand up a little straighter, arch my back a little, and stick my tailbone out in order to engage my butt muscles. This helps a lot with my knee issues.