After a 300 mile - 4 day AIDS ride 2 years ago I developed the dreaded saddle sore - after that healed it was (is) a constant battle to keep things under control. I found that my problem initially was the shorts - and not the seams on the chamois BUT the seam on the leg where the chamois was stitched on the short.

I found that the only shorts that work are the Performance bike (gel) one with the soft edges. I just bought a pair of their new ultra shorts and look forward to trying them out - (see link)

http://www.performancebike.com/shop/....cfm?SKU=18521

That being said, I have tried it all - Chamois Butt'r, Bag Balm, etc etc...the best thing that works for me - and lasts - it Body Glide. It is not as thick or gooey as the others but seems to stay put. You can also buy the travel size for your seat pack and reapply if needed on the ride (need to be a bit brave for this esp with a group of guys).

And the saddle - I have a Terry Butterfly that I rode used last year and have a men's WTB Rocket on order. The Terry Butterfly just does not cut it (maybe another Terry some other time) - I am petite, no hips, narrow pelvis so I guess it is time to try a mens saddle. I spoke with the local bike shop guy and he says it is really hit and miss with saddles (which was not very encouraging )- and to keep trying. He also recommended that I look for a saddle with thigh glides like the fizik or the wtb that I ordered. A good site to compare saddle -

http://www.xoomgear.com

this is the only time I wish I was a man - they have problems as well but it does not seem to be as bad!

good luck!