I live in fear of flats. I can do the tire part, but I have great difficulty getting the back wheel back on, the derailleur, etc. and remembering how to use the CO2 cartridge/inflator. I know all of the tricks, but the fear was paralyzing me. I got Gatorskins 3 years ago and I have not had a flat since then. I feel more confident about riding alone now.
I used to have the Conti 4000s, which were super easy to get off and on.