My parents have been "full timing" for more than 20 years now… I couldn't live that way, but they love it. They don't have a home base period, they've been using various relatives and friends homes as their address. They criss cross around the states and Canada for the most part. They've made little forays across the border into Mexico, but haven't spent any significant time there - I don't think even over night. They follow the good weather around and try to visit all the little stuff that mostly gets missed if you are traveling quickly.

One note about dogs - if you do travel with a dog it can still be difficult to visit some places like national parks. Dogs aren't allowed on trails at all - basically not outside of parking lots and some campground areas and you cannot leave them alone at campsites or in vehicles (including motorhomes), so what you can actually do there is very limited. I think my parents (or at least my dad…) might like to have one, but they haven't for that reason.