I have read reports that long-term use of ibuprofin has been tied to kidney and liver damage, as well as gastrointestinal bleeding. I can't remember how long term it would need to be before you would need to start worrying about it. I think it would be safe to use it occasionally, but could you try Tylenol sometimes? Of course, IB is what usually works best for me too. I do worry about taking on a daily basis though.