Thanks for your insight, Indy. The Synapse that I'm riding has a pretty relaxed geometry, as say, compared to my previous Cervelo which was extremely aggressive and racy. And the fitter that I just worked with (the PT fitter), thought that the geometry of my bike suited me well. He made some fairly significant changes to my saddle position (tilt, moved forward and up) and cleat position which seemed to have addressed some other pain issues that I was having. I was hoping that those changes would have resolved my hand issue, but sadly it did not. It improved it somewhat, but I was hoping for more. I honestly don't know what more could possibly be done to get me more comfortable, aside from going to a ridiculously steeper stem. The stem I have on there now is an 80mm, 17-degree...so it's fairly upright. I suppose I could try a steeper stem (I've seen a Ritchey one that is 30-degrees), but I think it would look rather silly, IMO. This is why I thought that perhaps it could be the bar itself...but I'm still not totally convinced of that yet. There is simply no way that I can even fathom looking at another bike altogether. So I have to figure out a way to work with this Cannondale Synapse. Another bike fitting is out of the question, too...as this last one cost me an arm & a leg.