I did the Canyon in one day (ran Bright Angel down and walked back up) and never again.
The best experiecne is getting down to Phantom Ranch... taken a shower and then exploring and meeting up and engaging with other hikers who come from all over the world! It's so cool! The dinner and breakfast at the Ranch is also fantastic! We normally go down Kaibab and return up Bright Angel. Someday we were reverse the route but for some reason what we have been doing makes sense.
My favorite trip took several days... we hiked down Kaibab, stayed at Phantom hiked out to the North Rim stayed at the grand Canyon Lodge, hiked back down to Phantom and then finished out on Bright Angel. I was really tired but it was a trip of a lifetime!