Yes to both.

MTB: I have had them on my MTB for years. Initially, they would always be flat because they didn't seal properly, but I think we fixed that. I don't use that bike much at all anyway.

Road: I just got them on my new road bike and so far I really like them. The wheels will go both ways, you can run tubeless or regular clinchers with tubes. I decided to go with a Hutchinson tubeless, the more durable model as opposed to the lighter one. They handle well and I don't notice a big increase in rolling resistance like I would expect from the lower pressures. The bike shop mounted them, so I don't know if there were any special needs to mount them.