Quote Originally Posted by Grog View Post
My favourite story is about grapefruit. I really dislike grapefruit. But some people have one a day, or more. Interestingly, when consumed in great quantities, grapefruit interacts with a lot of other drugs, with adverse effects. I think it can also curb down the effect of birth control pills. I'm really glad I dislike grapefruit.
Actually you don't have to eat a lot of grapefruit. Grapefruit is a cytochrome P450 (CYP3A4) inhibitor. If a drug is metabolized by CYP3A4 enzymes, then the drug won't be metabolized as quickly if you are drinking or eating grapefruit and you run the risk of too high a blood level of the drug. We usually tell people NO grapefruit if the drug is one that will be affected by inhibition of CYP3A4. My sister is currently on one such drug.