My $.02 is - you spend most of your waking hours at work, and it's not worth it if the job makes you miserable or constantly angry. Life is too short. I did a career change 10 years ago and I'm really happy I took the plunge. In the short run my salary was cut in half when I started over. Now it's not as high as it was when I had the soul-sucking job but it's close enough. I'm not rich but I have enough money to live better than most people. And the stress from my job is no longer making me ill.

Good luck with your situation.