I think John covers the basics on the videos, but we were with a week, so there were lots of details, bottom line is I think it's very difficult to say without a very good bike fitter helping you.
I've gone crazy with fitting, I've been professionally fit, John Howard gave me several good pointers and I've experimented myself. My legs vary some as I believe many peoples do. My chamois also use to slide to the side about 1/2". So I tried Lemond shims (I still use 1 for each shoe), but I've tried tup to about 6 on one leg. The shims I use now are for tilt. I've adjusted my cleats, fore and aft of each other, sliding the cleat of the longer femur forward, and the other back a bit. I've even enlarged my seatpost saddle binder so I could shift my saddle off center a hair.
Nothing seamed to really make a difference, so I've basically gone back to neutral and stopped trying to figure it out. I never did have pain, but just wanted the best fit. So other the one LeMond shim under each cleat, my bike setup is "normal". A I've not had problems with mileage or pain (longest ride is the RAIN ride in around 9 hours for 160 miles).
So I would go with what makes you comfortable, but if needed find a good fitter and work with them.
If I lived near San Diego, I would go to John, and I'm sure he would dial me in on the bike, give me a stretching routine especially developed for me, and make some corrections. But I live in Indiana, my fit is close, and I don't have any comfort issues, so I just focus more on getting faster and riding.
Best of Luck - it's a very interesting subject...



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). In fact, I have now bought 3 systems since my first was on a bike that was stolen. Talk about a drag, on top of the cost, I couldn't ride for 2 months while he remade it, which is why I had him make me 2 at once (cheaper also to make 2 at once than 2 separately).
