I found that I was able to feel many of the positive 'effects' of a cleanse by cutting out most of the processed foods, and eating more veg and fruit and whole grains and water. Personally, and in my fairly uneducated opinion, I think the biggest 'toxic' issue is the toxic effects of constipation. If you do a cleanse, or if you change to a more fresh-food-based, higher fibre diet, you get things moving and feel better over all.