I'm only familiar with what Prednisone does to my dog, Murphy (pictured in Avatar). He has seasonal allergies which causes him to lick and pick at his feet until they're red and scabbed over. The vet prescribed predisnone and he didn't respond well - could not control his bladder. Even half the prescribed dosage caused him to pee in our bed. Needless to say, we don't give it to him anymore.

Hopefully it doesn't have the same reaction in humans!