Hard and awkward though it may be, I think it is best to gently and kindly tell your friend the truth. Be kind but firm...no need to lecture. It will actually be doing your friend a favor in the long run.
If she gets mad at you then oh well, she needs more time to face her problem. She needs to be made aware that her problem has very real effects on her life and on others around her. Telling her in a kind but matter of fact manner is the best thing any friend could do for her. Sometimes friends need to be brave.