I have also been on a quest for the perfect shorts because my lady business starts to burn after about 20-25 miles. I keep missing out on those Castelli's on SAC!!! However, I just got a pair of Canari Women’s Velo Pro Gel from Performance and they were fantastic on my first ride. Most comfortable shorts I own so far. I'll wear them again tonight and on my 52 mile ride Saturday and see how they really stack up. (NOTE: They run big! Order one size down.)

I agree that if the shorts are too big, they will cause more pain.

I have seen the new chamois design and want to give that a try, too.

And I'm still coveting those Castelli's, but don't want to pay the price when I know they can be had for much less on SAC!