Definitely worth giving the bike a try- (but don't buy it if it doesn't fit).

I have a custom fit road bike- and there doesn't seem to be much standover clearance (especially in the front- it's got a sloping top tube) and it doesn't seem to bother me. The reach is so much closer on this bike than on my previous road bike which has been great. Make sure you look at the overall fit, not just the standover. I think having minimal standover should be fine- but there's obviously a line you don't want to cross.