So I've lived here 4 years... after living in Phoenix for 10 (with a detour to far NoCal inbetween). In Phoenix directions and streets are N, S, E, & W for the most part.
But not in N.O., oh no! Up river, down river, towards the river, or towards the lake. Technically you drive east to the "west bank" if you go across the bridge closest to the "CBD" (central business district). I still get lost.

I miss mountains, and topography.