The girly bits do get immediate relief. The rest of you will get used to where the saddle meets the bod, but setup is important. I would recommend putting it in the same forward/back position as your old one. As to tilt, go the same way. Then sit it without changing for a week of riding.

On mine (older model) the nose actually has a slight slope downward. I had to make sure I was leveling the back with the beginning of the slope (top) rather than the end of the nose.

Is this making sense?