I had this problem too. I have Izip E3 metro; Trek hybrid (with straight bars) & road bike with drop bars. I have had bike fitting & all are adjusted properly. I find that I have to change my hand position on all 3 bikes during the ride. The straight bar bike has the least options due to not much space & I have ordered aerobars for that bike. I also have tried several different wrist/carpal tunnel supports by Carpal Mate. The one that worked best came from amazon & the simplest of all & best. It is kind of L shaped with velcro around the wrist. That prevents the pressure on palm/"heel of palm." Bought larger gloves then realized I can use original gloves & just put the wrist support over the top. I tried riding today without them & definitely noticed the difference. I also have been doing more sit ups & core strengthening exercises in order to lean on bike less. I also tried different gloves with the little palm cushioning. Wasted my $$. The Carpal Mate helped more than anything else. I recommend you buy 1 see if it helps & then buy the 2nd one if you like it.