DH was on a pretty high dose (60 mg/daily) for 6 weeks last year for his Crohn's. It made my normally mild mannered husband irritable and short tempered. He also had crazy mood swings including feeling depressed/hopeless. Some of his mood I attribute to his life changing diagnosis of Crohn's, it is pretty hard to hear you have a chronic disease. He also gained 30 lbs but again he was on them for 6 weeks. Just follow the doctors dosage and make sure he tapers you back off. I am pretty sure you cannot quit cold turkey.