My husband used to travel almost weekly, for 4 days, when my kids were little. It was very stressful because the childcare arrangements changed. But I had those little boys to keep me busy!
Now my husband travels to Europe every other month. He is leaving in an hour for Sweden. I hate it when he goes, because it involves leaving on a Saturday... but I find that after the first day/night the time goes quickly. I always make a lot of plans so the time goes quickly. I plan rides with others I don't see that often and my friends usually extend dinner invitations. Nothing here is really different. My house is already quiet and we already eat less, like salads and sandwiches for dinner a lot of nights.