Whatever the reason CO2 doesn't stay in your tires, here's how I deal with it. I use a CO2 inflator for roadside flats. When I get home, I completely deflate the tire and reinflate with my floor pump. The CO2 really is just an emergency measure to keep you riding with a tire at full pressure. They are favored by my riding partners because they are so much faster. But I had a friend drop out of a ride last year because he had three cartridges and four flats. I suppose after flat #4, he was so far off his PR finishing time it wouldn't have mattered much if he'd had another cartridge.



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