I agree, NWG, I stand with some frequency to crest a smaller hill just because it's easier than shifting, often. It does take more upper body strength and aerobic capacity than sitting and spinning, so I find that if I am getting tired on a ride, I stand less and less than when I'm feeling "frisky" and energetic. 
I think it would be great if the 1x gearing system would come over to the roadie world! I guess the key would be getting the right size ring in the front for your style of riding, strength, etc. It might be more difficult for manufacturers to choose a chainring that would work for most riders in that kind of setup.
Crankin, I do know about downshifting to the granny by first upshifting ahead of time. When I first started riding fairly seriously on the road, I did a lot of reading on proper techniques and also learned a lot from my DH and folks in our club. So I actually do do that frequently when approaching a hill that I know is going to require the granny. A few in our old neighborhood in NC come immediately to mind.
I think part of the issue here is that we are traveling most of the time, so I am very often riding in unfamiliar areas on roads or paths I've never scoped out before. Sometimes, especially on a new route, it can be hard to visually judge a hill on first sight, or if it curves partway up. To me, part of becoming stronger and faster is not to use the granny unnecessarily and be spinning crazily, but of course to have it there if I need it. If I see a monster climb coming up, like some of the ones we did out west and in the northern plains last year (Teddy Roosevelt NP Scenic Loop springs to mind -- ack!), I shift to the granny in plenty of time. I think my issue is more with hills that look doable in the middle ring, but they end up being a bit longer or steeper than expected, so my cadence drops, and I think "shoot, I should have shifted to the granny back aways...but if I just had ONE more gear, I would be fine in the middle chainring. I am definitely a spinner but have been very fortunate not to have any real knee issues even if I do have to mash a little to get over the occasional hill.
The 42-25 (middle ring to largest in back) combination does not sound like cross-chaining (i.e., no ugly noises result). My understanding of cross-chaining was always that it occurred when in the inner ring up front and outer 2-3 gears in back, or the outer ring in front and the inner 2-3 gears in back, but that in the middle ring all gears in back were fair game. Not so? If that's the case...I've been doing it wrong for a few decades. It's certainly possible!
Emily
2011 Jamis Dakar XC "Toto" - Selle Italia Ldy Gel Flow
2007 Trek Pilot 5.0 WSD "Gloria" - Selle Italia Diva Gel Flow
2004 Bike Friday Petite Pocket Crusoe - Selle Italia Diva Gel Flow