I too am big chested (DDD) and really like enell's motion control bra:
http://www.enell.com/
This is the only bra I've worn while working out that I can honestly say I never have to give a thought about my boobs (comfort, chafing, jiggle). I can wear it cycling all day (or any kind of exercise). This is probably not the first piece of clothing I'd grab before greeting hubby at the door (not to mention it would take him awhile to get through the 13 hooks on the front of the bra) -- It definitely lacks sex appeal but does the job!
These bras are pricey but google around -- you can probably find it for just under $50.