I keep waiting for the nurses amongst us to answer this one, but haven't seen any (that I know of) taking hold of the thread. Let's see if I've absorbed any nursing knowledge from researching their working conditions from time to time ...

I'm wondering if a saddle sore is anything like a bed sore, also known as a pressure sore ...? If so, then you might find treatment options by googling those terms. Also if so, the cause is poor circulation, often due to pressure. So logically the long term solution, so as not to get another sore in the same spot later, might be hmmm ...? a different seat? better bike shorts? circulation breaks from time to time (i.e. stand, or even walk a bit) while biking?

Now come on nurses. I know you're out there. Correct me if I'm wrong here. Supplement me if I'm merely underinformed.