I'm a big-toe-pusher and sweat up a storm.
My solutions are clipping my big toe-nail often and emery-boarding the heck out of it, and wearing Smartwool socks.
You can get cheap Smartwools at Sierra Trading Post. They always have clearance ones or seconds for 1/2 regular price. www.sierratradingpost.com



I really want to buy several pairs and rotate them better, but I would like any advice on good socks that resist a little more wear in the (big) toes. I do have a couple of blisters on my feet (bottom of my big toe) that are possibly not sock related (could be shoes, could just be building resistance on my "dainty" feet). My feet also tend to sweat a lot, right now I have some PI X-static socks that are literally wet after running for an hour (then my feet get cold if I get on the bike to go to work).
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I'm not sure what my PI socks were, but I was quite saddened by the newly formed hole.
. The socks I wear snowboarding are Smartwools and I really like them. I know my feet sweat snowboarding, too, but I never notice wet socks (unless I bury myself in the snow or something, but that's a different issue 