The south was home to many thriving Jewish communities, and there are remnants of many of them. Even in Columbus, I saw glimpses of this, stores that had been in business for 70-100 years now going out of business, because the original owners' descendants no longer want to be shop owners. Jews were owners of dry goods stores, restaurants, and often the town pharmacist or physician. Pretty much after WW 2, this started changing. I remember a long time ago, my parents had friends who moved to Atlanta; the guy was a liberal rabbi. They were back in MA after a year or two. They couldn't take the racism of the area in the late 50s/early 60s.
There's a lot of family history hidden in those old cemeteries. I have never been to Charleston. It's on my list.