NY, I have always had issues with "itchy seams," waistbands, anything that touches more than lightly. I think it's got something to do with allergies. When I was struggling with asthma and hives in the late 80s, both my pulmonologist and allergist noticed that the hives were always around where my tights/leotard/shorts (aerobics days) were seamed. As a kid, I complained bitterly, and I remember making my mom so mad, she ripped a pair of pants off of my legs (she really was not a horrible violent mom). If certain tops touch me the wrong way on my left shoulder, I get red blotches. About 8-9 years ago, I got obsessed with merino wool. I always wore wool as a kid, but then came 23 years in the sunbelt. Merino never bothered me, but in the last 3 years, I have developed sensitivity, to the point where I had to take Claritin to wear my Ibex. It wasn't so bad last winter, but I think maybe because it was so warm, I didn't wear it as much.