I also have one spot that gets irritated no matter what I do. Since it's only one one side I figure it's due to a leg length discrepancy or something about the way that foot is angled -- my feet are not symmetrical due to surgery on the right ankle back in the '90s. But I don't feel like dealing with the trial and error of trying to address it and potentially causing other problems as a result. I do find that the right shorts make a difference, as does lots of chamois cream for longer rides. Then I use the chamois cream as a moisturizer for a few days after a long ride to help the skin heal.

I usually only ride my bike a couple of times each week. I supposed if I wanted to ride every day I'd need a better solution.

I'm curious about using Nu-skin, which I remember using once or twice on cuts or blisters when I was younger. I would worry that a band-aid would come loose and cause worse chafing.

Since last winter I've been having problems with chafed skin around the armpits. At first it only happened after bike rides and I hoped it would go away when summer arrived and I was wearing sleeveless jerseys instead of long or short sleeves. But this summer some of the sweaters and t-shirts that I wear to work have caused it, too -- large seams or scratchy fabric are a problem. I've been okay lately by using lots of Aveeno lotion twice a day but am concerned about what will happen when I have to start wearing sleeves again. Chamois cream on my skin and on the fabric under my arms helps a bit but I was thinking of trying something like large band aids or first aid tape to cover the skin. Maybe I will try Nu-skin and see if that helps.