I am very prone to these types of saddle sores. Sometimes they will come to a head and I can swab them with alcohol and take a sterilized needle to them, which sounds awful but can relieve a lot of pain and pressure if there is pus and blood in there. Sometimes no matter what I do they won't come to a head and become exquisitely painful and inflamed. Twice during two separate summers, I had my dermatologist do a cortisone injection, and that was a miracle cure! A couple of days later they totally shrunk up, and I could once again ride pain-free. I have had these on different bikes and with different shorts, and I think some people are just more prone to them than others (my DH gets them too). The more miles I ride, the more likely I am to get one. The one advantage of my very small weekly mileage right now while we're living in Mexico is that I don't get saddle sores.
Emily
2011 Jamis Dakar XC "Toto" - Selle Italia Ldy Gel Flow
2007 Trek Pilot 5.0 WSD "Gloria" - Selle Italia Diva Gel Flow
2004 Bike Friday Petite Pocket Crusoe - Selle Italia Diva Gel Flow