I tend to look at directions first on Mapquest, and then use my slightly older Garmin plug in GPS as I drive. Truly, I don't drive in unfamiliar places much anymore. I just don't like it. I had to do it a lot in my last job, though, and it wore me out, as most of it was in less than desirable areas. I don't know how to use the navigation on my I Phone... I mean, I know that if I click on it, it starts at the place I'm at, but I don't know how to program in where I want to go. Nothing about technology is intuitive to me, so if I have to use it, someone will have to show me.
I used to read maps very well, but now I never use maps. I would say I have a good sense of direction, but mostly in places where I slightly know the area, not in totally unfamiliar places. I get slightly uncomfortable hiking in the woods or x country skiing, if I am not on a route I've been on before. We use GPS when doing those activities, mostly because I am overly cautious.