I have had several chronic saddle sores that would just keep filling up with blood and pus over and over -- right on the infamous leg "crease" area. In two cases I eventually got fed up and asked my dermatologist for a cortisone injection, which provided immediate relief and healing.

When I was in Belize I got another one in basically the same place (sometimes it's on the right, sometimes left, but always in the same approximate place), and having no access to a dermatologist, I just kept draining it (pricking with a sterilized needle, squeezing, then putting a bandaid with antibiotic ointment on it), and it eventually went away on its own.

The past year back in the US I've put in a lot of miles and amazingly have had no saddle sores. There's no good reason why (shorts, saddles all same or similar), just good luck, I guess. And possibly riding in dryer, less humid conditions for the most part.

Saddle sores can s u c k it!