I prefer Looks over SPD's because I have, in fact, been standing on a roadside trying to get clicked into SPD's, no less than 20-30 times in a row without managing. Screaming at them!!! That should probably go into the embarrassment thread. Same in Spin class once.

I am starting to hit the Looks without even looking (erm - pun not intended) most of the time, especially because of the way they are weighted to be in the appropriate position for you.

OTOH, with MTB shoes and SPD cleats, you can step down on the pedal without being clicked in in an emergency, which is hard with Looks.

I guess it is really just a matter of preference.

And yes, I believe the KEO pedals have different cleats.