The route for Lotoja has changed significantly since I last rode it. There is significantly more climbing. There are 2 major climbs in the first 125 miles. I've ridden them both on separate occasions. Strawberry (the first climb is close to an hors categorie in the tour. Gains almost 3,000 ft in elevation with 2 steep sections I charted at 7.5% & about 3 miles long each. The second climb is Salt Creek pass that is pretty consistent at 5% with a steeper section close to 8% near the end. After that, the course descends to the valley and is only a gradual uphill to the finish. If it's a tail wind, awesome, if it's a headwind, it's crying time. She'll also be at elevation (+7,000 feet), so take this into consideration if she's coming from sea level.
When I raced it, it took me just over 8:30, when I rode it as a tour, it took about 9:30 in a strong group. I'd guess to have her plan on 9-10 hours from what people tell me.
The best advice I can give is to mentally keep yourself in the ride. Over 200 miles, most people have 2 or 3 emotional crises (I averaged about 4). Have her keep in mind that each feed zone is approximately 35 miles apart. Just focus on getting to the next feed zone and you can ride through the heart ache.
Tell her not to try and ride alone, stay in the bunches and bridge to the next group up when they're in sight. Find a group that suits her pace and stay with it as long as she can. The only time I would advise going solo and trying to break away is well into the Snake River Canyon. There's usually a tailwind in the afternoon and it's a mild gradient with enough turns, you can loose a pesky competitor. If she's racing for a place, tell her to hold wheels as long as she can from the beginning. The race goes in fits and starts and over 200 miles, the attacks don't last long. Just hold on & she'll get a chance to recover. It's a lot better to drop back if you can't keep the pace than trying to go solo to find a faster group.
A race this long requires a lot of planning in the support. One trick I learned was to determine in advance where in the feed zone (front or back) the support will meet her and to be there in EVERY feed zone - make sure the support is wearing identifiable clothing. This eliminates looking for them and she will get through the feed zone without incident.
Don't rely on hi-tech foods. Advise her to have real food in her bags. PBJ's ham & cheese sandwiches at least twice during the race. Also, have a packet or 2 of Enervitine's (high calorie liquid) handy in case she bonks. It will get her through to the next feed area. Musset bags are an advisable investment - also, those string backpacks that a lot of places give away work well.
One last trick, at feed zone 6, have a water bottle of chilled (but not too cold) Coke that's gone flat. Feels great on the tummy and the little caffeine & lots of sugar provide a much needed boost. And don't be shy with the Ibuprofen. Butt & shoulders get real sore after 6-7 hours in the saddle. Take lots. She'll metabolizing it pretty fast.
One last thing, tell her if she's getting really sore, to get off the bike for a few minutes and stretch. Also, tell her to stretch during group bathroom breaks - this really helps a lot. A 2 minute break can save close to an hour cumulatively in increased riding efficiency.
Tell her good luck.