The only bike I've owned that didn't give me a hard time moving up to a bigger front ring is my mtn. bike with a Shimano triple -- it has a really light touch in every respect. Road, mtn, and CX bikes with X5/X7, 105, Apex, and Rival have all been a challenge because I have shortish, girly fingers and hands. This stuff is not designed for us, unfortunately. Now that I have a weakened right hand and wrist after my wrist fracture I find that my SRAM stuff is a bit difficult to operate on that side, too...even though it was no issue pre-injury. I definitely see the appeal of Di2.