What does help, especially if one doesn't know anyone well in a newish city/city that's hard to like, is regular contact with loved ones/a friend. The Internet makes it even cheaper these days. I know it's not the same as person in the same physical spot where you are, but if it means providing a sense of personal continuity and equilibrium, keeping relationships meaningful and engaged, then do so. As long as it's a 2-way street/dialogue, giving back to and for with the other person.

Where I am, there a lot of defectors from Ontario, other provinces and some from British Columbia like myself..simply because of a job offer. Calgary is the fastest growing large city in Canada at this time. However that may be slowing down a tad.

The problem is that people are friendly, interested but their commitment to the place/city is not quite there.