I use eggbeaters on my road bike. I know they're not road pedals, but they're just so darn easy to get in and out of. They were my first clipless pedals and I'm still satisfied with them. I mostly ride shorter distances (30 miles, give or take) but I've done a few 50-60-70 mile rides too. I did get hot spots once, when I was wearing cheaper, softer soled shoes. When I wear a decent shoes I don't have any issues even on long rides. My "good" shoes are Diadoras and they do have a little rubber tread, but they also have a nice stiff sole. They're basically road shoes with tread added, according to my LBS. Oh, and I have a bad knee (old ACL and meniscus repair) and have never had issues with the eggbeaters. So they're a viable option, along with the other good pedals that have been mentioned here.
Edited to add: the pedals I'm talking about are Candies, so they do have a bit of a platform
Last edited by ZenBiker; 03-25-2013 at 07:12 PM.
Road bike: Specialized Ruby Comp (2011)
Commuter: Salsa Vaya (2012)