Well, my DH is on statins, bp meds, and is in awesome physical shape .Definitely not sedentary. Some of us can't fight our genetics. He's pretty pain free, too, although, I think age is catching up with him a little. Me, I think I have just accepted this is the price I pay for weighing the same as I did in HS!
Funny, DH's cardiologist was a little discouraging to all the intense exercise when he first had the stents put in, but now, he accepts it. We are all outliers.