The danger of asking TE members for advice....we'll probably always pick the bike that has the better components.

If you have the money, the 2012 S-Works sounds like an AWESOME deal! See if you can get a bike fit included with your bill.
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2012 Specialized Amira Elite, upgraded carbon handle bars, Jett saddle 143mm switched to 145mm 2012 Selle Italia Max SLR Gel Flow saddle
2010 Santa Cruz Juliana with R kit and Crampon pedals
2011 Specialized Ariel Sport,suspension post,Serfas Rx Women's Microfiber saddle (sold)