I needed a whole combo thing going before I eliminated that issue completely. No one thing did it. My now pefect "system":
-Brooks B17 saddle broken in. Wallbike has a 6-month return policy if you're interested.
-The chamois in Rapha shorts. Stupid expensive, but I got them 50% off and having two pair I love cost less than all the buying/trying I was doing before.
-Lady Anti Monkey Butt anti-friction powder. I prefer it to chamois cream. Just get in all the nooks and crannies and it's a big help, at least for me.
-I had my...er...undercarriage lasered off years ago, but keeping the rest nicely trimmed is key to be irritation free.
-Serious core work. When I started cycling a few months ago, I was in horrible shape though I hadn't really thought so. I've since learned that having a strong core makes a huge difference. If it's weak, I start drooping, putting too much pressure on hands, lady parts, throwing off my pedal stroke, etc. I also hate doing core work, but the results are worth it.

I hope you find a saddle that works or you. That's definitely the best place to start, but other things also help. Good luck!