I know everybody has what works for them, but have you thought of trying a Brooks saddle? After a couple hundred miles, the leather starts to more or less become your saddle with your butt imprint right there for you to see. Other than the expected sore sit bones when I was first getting used to riding and breaking in the saddle, and now on only longer rides, I've had zero issues. I don't wear Chamois cream, though have recently become fond of Lady Anti-Monkey Butt Powder. I've been riding about 100-200 miles weekly since I got the saddle, and although the longest ride I've done so far is 52 miles, there's a reason these saddles are used by most everyone (okay, mostly men) for touring. It might be worth a shot. I got mine from Wallbike, and they have a 6-month return policy.