My advice is to do some serious test riding AND get a real fitting. I'm 5'6" and have a 31" inseam. Most road bikes that I have had over the years have been in the 54 cm range. Most road bikes that I have had have not been very comfortable.
I now have a 49cm (EDIT) road bike that fits me like a dream. It's wierd because one would think that a 49cm would be way to small for me, but it's not. I had a pro fit and everything is perfect. It's the most comfortable bike I have ever ridden (and I've ridden ALOT of bikes!)
Bike fit is part science (fitting) and part art (intuition and what feels right).



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