I think I have found the almost perfect saddle with the Selle Italia Diva Gel Flow.
The only thing I am not sure about is that it is a little wide in the nose and may rub the area where the thigh and the crotch meet. Time will tell. So far I have done a 20 mile ride and a 14 mile ride with it and it is so comfortable. I don't feel like I am balancing on my seat bones anymore. No tenderness after the ride. They feel cradled without being squishy.
The opening relieves any pressure on the girly bits. I thought my old Avocet 02 saddle was great until I took it out for a spin and realized it was not the wonderful saddle I remember. I have tried numerous saddles in the hopes of finding that perfect one, and I really think this is as close as they come.