If the hills are that bad on the first day, I would constantly remind myself to spin up them. That late in the ride, you might be tempted to mash up them to get it over, but I know that if I mash on a 200k, my knees are shot the next day. And, well, on the next day, you've got a sizable ride to do again. So do what you can to take it easy on the first day. You can hammer on day 3 if you want.