Yup...I have. I'm on Advair 250/50...have been for about 10 years now. I've always been under the impression that any type of long-term corticosterioid use can have the side effects of weight gain and bloating. I can tell you for sure, that during times when I had acute attacks and was put on a course of prednisone, I would for sure pack on the pounds and get all puffy. It's weird though, because if you read the literature that comes with the prescribed inhalers and such, it generally doesn't list weight gain and bloating as side effects...yet I do think they exist.

Linda