I have tried every type of short and changed saddles, but I still have butt issues. I started developing a hot spot after only 20 miles last week, so I decided to try a preemptive strike. I put Tegaderm over the spot where I usually have trouble before my last ride, and it seems to have helped. I rode for only around 30 miles, so that's not the best test, but I'll see what happens after a longer ride.
I think part of my problem is one of my legs is longer than the other, so I have problems on the crease between my leg and butt on the right side. Might try to try something about that too, but in the meantime, I think I may have found at least a stopgap solution.
Has anyone tried this or something else? I am now using Mad Alchemy Pure Chamois cream, which has shea butter in it, which is the best I've used, but the Tegaderm seems to be doing the trick.